Please Note: Regenerative Mesenchymal Stromal Cell (msc) Therapy has been temporarily halted pending regulatory changes by the College of Naturopathic Physicians of BC. We intend to resume offering the treatments as soon as possible. If you are interested in receiving this treatment, please call the office and put your name on a wait list and we will contact you when we resume.
Apologies for any inconvenience.
Regenerative Mesenchymal Stromal Cell (MSC) Prolotherapy from Fat
Regenerative prolotherapy medicine is continuing to advance. Originally, it began with the injection of dextrose and other irritants such as P2G, to stimulate inflammation and the flow of growth factors to the target area. Platelet Rich Plasma (PRP), proved to be a great advancement as the platelets contain high amounts of the growth factors stimulating the regrowth of the damaged joints, cartilage, tendons and ligaments.
We now have available the technology to isolate a patient’s live regenerative cells from their own fat to stimulate regeneration at multiple factors of effectiveness than that possible with platelets alone. Our abdominal fat contains stromal vascular fraction cells, also termed mesenchymal cells (msc). These immature cells have the ability to differentiate into mature tissues like cartilage, tendon, bone, and ligaments.
This is new technology and is experimental as is. The medical literature supports its use in animals and there is a growing literature supporting its use in humans. The clinical evidence is very encouraging.
Originally it was thought that stem cells isolated from embryonic tissue could be used as the regenerative medicine. Besides the ethical issues involved, there were problems with tissue rejection (it is a form of transplant). The earliest research involved cells extracted from bone marrow and most of the current literature is based on this research. In the 1990’s it was discovered that regenerative stromal cells are abundant in abdominal fat and much easier to extract than from bone marrow. Early research is demonstrating a comparable regenerative benefit from adipose derived cells as from bone marrow.
The goal of Mesenchymal Stromal Cell (MSC) Prolotherapy:
The goal with all forms of Prolotherapy is to have each person return to their optimum level of activity with improved function and no pain. You should be able to do what you want to do and not be limited by a diagnosis of osteoarthritis. The “curse” that “you have degenerative arthritis, expect to get a joint replacement” may not be inevitable. It is our hope that regenerative MSC prolotherapy may provide sufficient regeneration that surgery may be avoided or significantly delayed.
How is it done?
The fat is extracted using a process called lipoaspiration, similar to liposuction, but done by hand in a gentle manner. Although there is some discomfort after the procedure, there are no stitches, and resolution is quick. The methods used at Integrative were developed by cell biologist Kristin Comella and regenerative physician Dr. Sharon McQuillan. The fat is processed using cell washing, enzymatic digestion and centrifugation. This process extracts millions of viable living cells from fat which are mixed with PRP for injection. The entire process from intake to injection may take up to 4-5 hours.
The Integrative Approach; What to expect;
At Integrative Naturopathic Medical Centre we combine advanced medical procedures with naturopathic methods. If you decide to receive Regenerative Mesenchymal Cell Prolotherapy you can expect the highest level of care. The single fee includes:
- Pre-treatment assessment
- Required Lab tests
- Prophylactic medication
- Post aspiration prophylaxis with ozone and homeopathic medicine
- Tissue healing IV while waiting for cell prep
- Injection treatment with ultrasound needle guidance
- Take home of all dressings, homeopathic Arnica, Traumeel cream and Chinese herbs to promote healing
- 2 follow up appointments with rejuveness lymphatic drainage to promote rapid healing of incision sites and doctor follow up
- 1 month follow up appointment
By Pat Hagan
Updated: 22:56 GMT, 11 November 2011
A revolutionary jab made from ... cells found in tummy fat could soon stop osteoarthritis in its tracks.
The breakthrough provides hope for the eight million people in the UK who suffer from the incurable condition and could potentially save thousands from needing joint replacement surgery.
Dutch and French researchers found injecting ... cells harvested from a patient’s own waistline protects joints against crippling damage. It appears to be the closest experts have come to halting the disease using ... cells.
The therapy works by stopping destruction of cartilage – the ‘shock absorber’ tissue inside which gets ground down by osteoarthritis – and by protecting ligaments.
A single dose of ... cells extracted from adipose tissue – fat which accumulates around the stomach – more than halved damage to knee joints in mice.
The findings, revealed at the American College of Rheumatology in Chicago, could mark a turning point in the search for a treatment. Osteoarthritis is the most common type of arthritis in the UK.
Pain free: The treatment could end knee surgery for arthritis sufferers
It can inflame and damage any joints, but occurs mostly in the knees and hips. Some joints become so severely worn down they require surgery.
As well as older age, risk factors include being overweight, a family history of the condition and sports-related injuries.
Many sufferers rely on anti-inflammatory painkillers to ease their suffering, but these can damage the stomach if used long-term. About 60,000 people a year end up needing a knee replacement.
Significantly, adipose tissue is relatively easy to access and is thought to be the most abundant source of adult ... cells in the body.
According to some estimates, it contains 40 times more ... cells than bone marrow. Scientists are already using these fat cells in the search for cures for cancer, heart disease and spinal injuries.
Researchers at Radboud University in the Netherlands, and the National Institute of Health and Medical Research in France, injected adipose ... cells into the joints of mice with arthritic knees.
The cells, known as mesenchymal cells, have the capacity to grow into a variety of body tissues.
Some mice received the jab seven days after osteoarthritis first set in, others 14 days after – which would translate into a few weeks or months in humans.
When it was given sooner, the jab cut destruction of cartilage by 54 per cent compared with those injected with a dummy jab. After six weeks, they had half the amount of ligament damage.
The jab also slowed a process called synovial activation, where the soft membrane around the joint becomes inflamed, in some cases by as much as 30 per cent.
British experts and charities including Arthritis Care last night welcomed the latest research.
Robert Moots, professor of rheumatology at the University of Liverpool, warned it was not yet certain how ... cells will behave in human joints.
But he added: ‘It is the strongest clue yet that ... cell treatments could make a big difference.’