It has been called the most important genetic factor associated with early atherosclerosis and coronary artery disease.* Other constituents, such as apo A-1 and apo-B are also important. Researchers from one Mayo Clinic study argued that specific apolipoprotein components of cholesterol—particularly A-1 and A-2–may be considerably better markers than cholesterol itself.** Researchers from Johns Hopkins asserted that apo A-1 and apo-B were better indicators of premature coronary atherosclerosis than markers such as LDL cholesterol.***

*Doetsch K, Roheim PS, Thompson JJ. Human lipoprotein(a) quantified by 'capture' ELISA. Ann Clin Lab Sci 1991;21(3):216-218.

** Kottke BA, Zinsmeister AR, Holmes DR Jr, Kneller RW, Hallaway BJ, Mao SJ. Apolipoproteins and coronary artery disease. Mayo Clinic Proc 1986;61:1.

*** Kwiterovich PO Jr, Coresh J, Smith HH, Bachorik PS, Derby CA, Perason TA. Comparison of the plasma levels of apolipoproteins B and A-1, and other risk factors in men and women with premature coronary artery disease. AM J Cardiol 1992;69(12):1015-21.