Fibrinogen is a blood protein that the body depends on for proper clotting, to prevent bleeding to death in response to injury. But if fibrinogen levels become too high, from stress, obesity, inflammation, aging, or other causes, this substance can play a key role in artery disease by restricting blood flow, accelerating plaque deposits, and promoting damage to arteries.1,2,3,4,5

1. Caen JP, Soria J, Collet JP, Soria C. Fibrinogen, a vascular risk factor. Bull Acad Natl Med 1993;177(8):1433-41.

2. Juhan-Vague I, Pyke SD, Alessi MC, Jespersen J, Haverkate F, Thompson SG. Fibrinolytic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. Circulation 1996;94(9):2057-63.

3. Lau CS, McLaren M, Mackay I, Belch JJ. Baseline plasma fibrinolysis and its correlation with clinical manifestations in patients with Raynaud's phenomenon. Ann Rheum 1993;52(6):443-8.

4 . Levenson J, Giral P, Razavian M, Gariepy J, Simon A. Fibrinogen and silent atherosclerosis in subjects with cardiovascular risk factors. Arterioscler Thromb Vasc Biol 1995;15(9):1263-8.

5. Giannasi G, Ferrari S, Galetta F. Fibrinogen as a cardiovascular risk factor. Minerva Cardioangiol 1995;43(5):169-75.